Advantages of targeted exome sequencing in contrast to whole-genome/exome sequencing?

First, we need need to know what is whole genome sequencing and targetted exome sequencing.

Whole-genome sequencing- as we all know our genome is made up of DNA which is further composed of bases. In whole-genome sequencing, the sequence of these base pairs is identified which is also known as DNA fingerprint. In whole-genome sequencing, the order of the bases in a genome is identified in one process.

Targeted exome sequencing- is a way to detect known and common as well as rare genetic variants in selected genomic regions or sets of genes. This process is fast and cost-effective and can be done by using various DNA sequencing methods depending on the need.

Advantages of targeted sequencing analysis:

• It can identify the genes and variants that are previously identified in the genomic regions.

• In clinical diagnosis, targeted sequencing can be used more efficiently to find the gene or the causal variants of the disease.
• It has a simple procedure of library preparation

• It has a short running time
• It can give a highly accurate result

• Targeted sequencing uses deep sequencing to identify the novel variants and known variants.

• This technique requires less sample input and produces less data which makes the interpretation of results manageable and easier.